I have read that the nodal axis across the asc desc axis is karmic in synastry..
This is a placement I have with my bf, and it is a relationship that goes way beyond *just* normal attraction/compatability, not sure if it means it's karmic, but I feel like we'd always be drawn to eachother magnetically regardless of bodies/personalities. In fact, we didn't see eachother for 10 years, and once we set eyes upon eachother again, that was it (exactly like 10 years before...spooky in a good way).